Dra. Libia Vega Loyo
Investigador Titular "Cinvestav 3D";, SNII III
Lab 30. Genética Toxicológica e Inmunotoxicología
5557473800 Ext. 5427
lvega@cinvestav.mx
Líneas de investigación
- Daño genético en la activación de células inmunes en poblaciones humanas, estudios in vitro y modelos animales expuestos a xenobióticos.
- Determinación de marcadores de susceptibilidad a daño genético, carcinogénico y alteraciones inmunológicas en poblaciones humanas; mecanismos moleculares de alteraciones en la actividad y funcionalidad de células inmunes.
Proyectos relevantes
- Desarrollo y caracterización físicoquímica de nanomicelas como vehículo de administración del antineoplásico ácido 6 pentadecil salicílico.
Publicaciones recientes y/o relevantes
- Styblo M, Del Razo LM, Vega L, Germolec DR, LeCluyse EL, Hamilton GA, Reed W, Wang C, Cullen WR, Thomas DJ. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Archives of Toxicology 2000, 74: 289-299. https://doi.org/10.1007/s002040000134
- Soto-Peña GA, Luna AL, Acosta-Saavedra LC, Conde P, López-Carrillo L, Cebrián ME, Bastida M, Calderón-Aranda ES, Vega L. Assessment of lymphocyte subpopulations and cytokine secretion in children exposed to arsenic. FASEB Journal 2006, 20: 779-781. https://doi.org/10.1096/fj.05-4860fje
- Vega L, Rodríguez-Sosa M, García-Montalvo EA, Del Razo LM, Elizondo G. Non-optimal levels of dietary selenomethionine alter splenocyte response and modify oxidative stress markers in female mice. Food and Chemical Toxicology 2007, 45(7): 1147-1153. https://doi.org/10.1016/j.fct.2006.12.021
- Gnanaprakasam JNR, Estrada-Muñiz E, Vega L. The anacardic 6-pentadecyl salicylic acid induces macrophage activation via the phosphorylation of ERK1/2, JNK, p38 kinases and NF-B. International Immunopharmacology 2015. https://doi.org/10.1016/j.intimp.2015.08.038
- Medina-Buelvas DM, Estrada-Muñiz E, Rodríguez-Sosa M, Shibayama M, Vega L. Increased heart fibrosis and acute infection in a murine Chagas disease model associated with organophosphorus pesticide metabolite exposure. Scientific Reports 2019. https://doi.org/10.1038/s41598-019-54218-7
- Galot-Linaldi J, Sánchez-Hernández KM, Estrada-Muñiz E, Vega L. Anacardic Acids from Amphipterygium adstringens Confer Cytoprotection against 5-Fluorouracil and Carboplatin Induced Blood Cell Toxicity While Increasing Antitumoral Activity and Survival in an Animal Model of Breast Cancer. Molecules 2021. https://doi.org/10.3390/molecules26113241
- Hernández-Toledano DS, Vega L. Dialkyl phosphate compounds and malathion disrupt cytoskeleton proteins assembly. Chemico – Biological Interactions 2023. https://doi.org/10.1016/j.cbi.2023.110593
- Capítulos de libro, artículos en revistas no arbitradas:
- Styblo et al. Metabolism and toxicity of arsenicals in cultured cells. En: Abernathy CO, Calderon RL, Chappell WR (Eds). Arsenic Exposure and Health Effects. Elseviere Science, pp. 311-323, 1999.
- Vega et al. Early signs of immunodeppression induced by arsenic in children. En: Natural Arsenic in Groundwaters of Latin America. Bundschuh J, Armienta MA, Birkle P, Bhattacharya P, Matschullat J, and Mukherjee AB (Eds) CRC Press, Taylor & Francis Group 1: 435-446, 2009.
- Tovalin et al. Air pollutants exposure and health effects: A multi-pollutant approach during the MILAGRO-MCMA2006 campaign. En: Air Pollution. Health and Environmental Impacts. Gurjar BR, Molina LT, Ojha CSP (Eds) CRC Press, Taylor and Francis Group 2: 203-228, 2010.