Anthocyanins of Hierbamora (Solanum nigrescens): Revealing their Nutraceutical Potential for Controlling Hypertriglyceridemia and Helicobacter pylori Viability



Te invitamos a leer el artículo "Anthocyanins of Hierbamora (Solanum nigrescens): Revealing their Nutraceutical Potential for Controlling Hypertriglyceridemia and Helicobacter pylori Viability"  publicado en Chemistry & Biodiversity, en el que colaboró el Dr. Edmundo Lozoya Gloria de la Unidad Irapuato.

Yesenia Pacheco Hernández, Edmundo Lozoya Gloria, Ramiro Cruz Durán, and Nemesio Villa Ruano

We present the inhibitory properties of the Solanum nigrescens anthocyanin fraction (SNAF) and its major constituents on alpha-glucosidase (AG), pancreatic lipase (PL), HMG-CoA reductase, and ornithine  decarboxylase (ODC). The effect of SNAF was simultaneously evaluated in ICR male mice exposed to triglyceride charge test (TCT). HPLC-MS profiling revealed the presence cyanidin-3-O-rutinoside-5-glucoside (CRG), delphinidin-3-(p-coumaroyl)-rutinoside-5-glucoside (DCRG), and petunidin-3-(cis-p-coumaroyl)-rutinoside-5-glucoside (PCRG) as major constituents of the fraction. SNAF, CRG, and specially PCRG, induced strong non-competitive inhibition on PL (IC50, 33–86 μgmL 1). The results of TCT confirmed their capacity to ameliorate (p <0.001) hypertriglyceridemia during  postprandial and interdigestive stages. SNAF, CRG, DCRG, and PCRG caused negligible growth inhibition (MIC>600 μgmL 1 ) on beneficial bacteria whereas SNAF and DCRG exerted inhibitory ctivity on Helicobacter pylori ATCC 53504 (MIC,187-64 μgmL 1 ). Additional exploration revealed that SNAF and DCRG produced noncompetitive activity on H. pylori urease, which facilitates bacterial growth under acidic conditio.


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20/07/2023 01:35:16 p. m.