REvolutionH-tl: Reconstruction of Evolutionary Histories tool

José Antonio Ramírez Rafael, Annachiara Korchmaros, Katia Aviña Padilla, Alitzel López Sánchez, Andrea Arlette España Tinajero, Marc Hellmuth, Peter F. Stadler & Maribel Hernández Rosales

Te invitamos a leer el artículo "REvolutionH-tl: Reconstruction of Evolutionary Histories tool" publicado en Comparative Genomics, a cargo de la Dra. Maribel Hernández Rosales de la Unidad Irapuato.

Autores:

José Antonio Ramírez Rafael, Annachiara Korchmaros, Katia Aviña Padilla, Alitzel López Sánchez, Andrea Arlette España Tinajero, Marc Hellmuth, Peter F. Stadler & Maribel Hernández Rosales

Resumen:

Orthology detection from sequence similarity remains a difficult and computationally expensive problem for gene families with large numbers of gene duplications and losses. REvolutionH-tl implements a new graph-based approach to identify orthogroups, orthology, and paralogy relationships first, and it uses this information in a second step to infer event-labeled gene trees and their reconciliation with an inferred species tree. It avoids using gene trees and species trees upon input and settles for a maximal subtree reconciliation in cases where noise or horizontal gene transfer precludes a global reconciliation. The accuracy of the tool is comparable to competing tools at substantially reduced computational cost.