Two orthogonal differentiation gradients locally coordinate fruit morphogenesis
Artículo
Te invitamos a leer el artículo "Two orthogonal differentiation gradients locally coordinate fruit morphogenesis" publicado en Nature Communications, a cargo del profesor investigador de la Unidad de Genómica Avanzada del Cinvestav Dr. Stefan de Folter, Profesor Investigador de la UGA-Langebio.
Autores: Andrea Gómez-Felipe / Elvis Branchini / Binghan Wang / Marco Marconi / Hana Bertrand-Rakusová / Teodora Stan / Jérôme Burkiewicz / Stefan de Folter / Anne-Lise Routier-Kierzkowska / Krzysztof Wabnik / Daniel Kierzkowski
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University of Montreal Canada
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Technical University of Madrid, Spain
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Unidad de Genómica Avanzada del Cinvestav (UGA-Langebio), Mexico
Felicitamos al estudiantado y profesorado que contribuyeron en esta investigación por su arduo trabajo.
Summary:
Morphogenesis requires the coordination of cellular behaviors along developmental axes. In plants, gradients of growth and differentiation are typically established along a single longitudinal primordium axis to control global organ shape. Yet, it remains unclear how these gradients are locally adjusted to regulate the formation of complex organs that consist of diverse tissue types. Here we combine quantitative live imaging at cellular resolution with genetics, and chemical treatments to understand the formation of Arabidopsis thaliana female reproductive organ (gynoecium). We show that, contrary to other aerial organs, gynoecium shape is determined by two orthogonal, time-shifted differentiation gradients. An early mediolateral gradient controls valve morphogenesis while a late, longitudinal gradient regulates style differentiation. Local, tissue-dependent action of these gradients serves to fine-tune the common developmental program governing organ morphogenesis to ensure the specialized function of the gynoecium.