Synthesis of New Isoindolines Derived from L-Α-Amino Acids and their Selectivity on Cancer Cell Lines
Autores. Teresa Mancilla Percino, Maricarmen Hernández Rodríguez, Elvia Mera Jiménez
Revista: Journal of Organometallic Chemistry
https://doi.org/10.1002/slct.202304299
Resumen: Isoindolines are essential from the point of view of synthesis and their biological properties, so this work is focused on the synthesis of new isoindolines derived from the following L-α-amino acids, aspartic acid (1), arginine (2), glutamic acid (3-5), serine (6), and lysine (7). All compounds were characterized by 1H and 13C NMR, infrared, and high-resolution mass spectrometry. In addition, the synthesized compounds were screened to investigate their antiproliferative activities against five human cancer cell lines, A549, U373, MDA-MB-231, MCF-7, and HeLa, as well as on primary cell culture healthy, MGC, EC, and Vero cells lines. All tested compounds exhibited activity against cancer cell lines at mM concentrations. Notably, compounds 6 derived from Ser, and 7 derived from Lys exhibited remarkable effects on the A549 and U373. The IC50 values for these compounds were determined to be 0.001 and 0.007 mM, respectively. These findings indicate a significantly higher potency of compounds 6 and 7 than the other tested compounds. Among the tested compounds, only compound 5 displayed significant cytotoxic activity against the Vero cell line.