5557473800 Ext. 3354 Lab 5530
Biólogo por la UNAM, Maestría y Doctorado en el Cinvestav. Posdoctorado en la Universidad de Northwestern en Chicago, USA. Estancias de investigación en el laboratorio del banco de cerebros de la Universidad de Cambridge, Inglaterra y estancia sabática en el Centro Psiquiátrico de Praga, República Checa.
-
Perla H. Horta-López, Graciela Mendoza-Franco, Fanny Rodríguez-Cruz, Francisco M. Torres-Cruz, Elizabeth Hernández‐Echeagaray, Jose J. Jarero-Basulto, Jan Rícny, Benjamín Florán Garduño, Francisco Garcia-Sierra. Association of α-1-antichymotrypsin expression with the development of conformational changes of Tau protein in Alzheimer’s disease brain. Neuroscience. (2022) Jan 8:S0306-4522(22)00002-1. doi: 10.1016/j.neuroscience.2022.01.002
-
Vanessa J. Ibarra Bracamontes, Jaime Escobar-Herrera, Zdena Kristofikova, Daniela Rípova, Benjamín Florán-Garduño, Francisco Garcia-Sierra. Early but not late conformational changes of Tau in association with ubiquitination of the neurofibrillary pathology in Alzheimer´s disease brains. Brain Research 1744: 146953 (2020). doi: 10.1016/j.brainres.2020.146953.
-
Francisco M. Torres-Cruz, Fanny Rodríguez-Cruz, Jaime Escobar-Herrera, Norma Barragán-Andrade, Gustavo Basurto-Islas, Daniela Ripova, Jesús Ávila and Francisco García-Sierra. Expression of Tau protein produces aberrant plasma membrane blebbing in glial cells through RhoA-ROCK-dependent F-Actin remodeling. Journal of Alzheimer´s disease 52:463-482 (2016). doi: 10.3233/JAD-150396
-
Francisco García-Sierra, Jose J. Jarero-Basulto, Zdena Kristofikova, Emerich Majer, Lester I. Binder, Daniela Ripova. Ubiquitin is associated with early truncation of tau protein at aspartic acid421 during the maturation of neurofibrillary tangles in Alzheimer’s disease. Brain Pathology 22(2): 240-250 (2012). doi: 10.1111/j.1750-3639.2011.00525.x
-
Janaky Coomaraswamy, Ellen Kilger, Heidrun Wolfing, Claudia Schafer, Stephan A. Kaeser, Bettina M. Wegenast-Braun, Jasmin K. Hefendehl, Hartwing Wolburg, Matthew Mazzella, Horte Ghiso, Michel Goedert, Haruhiko Akiyama, Francisco Garcia-Sierra, David P. Wolfer, Paul M. Mathews, Mathias Junker. Modeling familial Danish dementia in mice supports the concept of the amyloid hypothesis of Alzheimer´s disease. Proc Natl Acad Sci USA, 107 (17) 7969-7974 (2010). doi: 10.1073/pnas.1001056107
-
Gustavo Basurto-Islas, Jose Luna-Muñoz, Angela L Guillozet-Bongaarts, Lester I Binder, Raul Mena, Francisco Garcia-Sierra. The progressive accumulation of neurofibrillary tangles composed of aspartic acid421 and glutamic acid391 cleaved tau correlated with the neuropathology and clinical severity of Alzheimer's disease. Journal of Neuropathology and Experimental Neurology 7 (5); 470-483 (2008). doi: 10.1097/NEN.0b013e31817275c7
-
Francisco García-Sierra, Siddhartha Mondragón-Rodríguez and Gustavo Basurto-Islas. Truncation of tau protein and its pathological significance in Alzheimer’s disease. Journal of Alzheimer´s disease 14: 401-409 (2008). doi: 10.3233/jad-2008-14407
-
T.C. Gamblin, F Chen, A. Zambrano, A Abraha, S. Lagalwar, A.L. Guillozet, M. Lu, Y. Fu, F. García-Sierra, R. Miller, R.W. Berry, L.I. Binder, V.L. Cryns. Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheime’s disease. Proc. Natl. Acad. of Sci. (USA)100(17):10032-7 (2003). doi: 10.1073/pnas.1630428100
-
García-Sierra F., et al., (2011). Pathological stages of abnormally processed tau protein during its aggregation into fibrillary structures in Alzheimer´s disease. In: Alzdisease pathogenesis; core concepts, shifting paradigms and therapeutic targets. pp. 131-156. Editorial: InTech open access publisher.