Enrique Hong- The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation

24 de enero del 2024

Invitamos a leer el artículo: " The Roles of MicroRNAs in Asthma and Emerging Insights into the Effects of Vitamin D3 Supplementation", realizado por el Dr. Enrique Hong, Investigador de Cinvestav Sede Sur

Autores:Adrián Hernández Díazcouder, Rodrigo Romero Nava, Blanca E. Del Río Navarro, Fausto Sánchez Muñoz, Carlos A. Guzmán Martín, Nayely Reyes Noriega, Octavio Rodríguez Cortés, José J. Leija Martínez, Juan Manuel Vélez Reséndiz, Santiago Villafaña, Enrique Hong y Fengyang Huang

Abstract: Asthma is one of the most common chronic non-communicable diseases worldwide, characterized by variable airflow limitation secondary to airway narrowing, airway wall thickening, and increased mucus resulting from chronic inflammation and airway remodeling. Current epidemiological studies reported that hypovitaminosis D is frequent in patients with asthma and is associated with worsening the disease and that supplementation with vitamin D3 improves asthma symptoms. However, despite several advances in the field, the molecular mechanisms of asthma have yet to be comprehensively understood. MicroRNAs play an important role in controlling several biological processes and their deregulation is implicated in diverse diseases, including asthma. Evidence supports that the dysregulation of miR-21, miR-27b, miR-145, miR-146a, and miR-155 leads to disbalance of Th1/Th2 cells, inflammation, and airway remodeling, resulting in exacerbation of asthma. This review addresses how these molecular mechanisms explain the development of asthma and its exacerbation and how vitamin D3 may modulate these microRNAs to improve asthma symptoms.

Keywords:asthma; inflammation; microRNAs; vitamin D3 supplementation