Guadalupe Bravo - Tomato lipidic extract plus selenium decrease prostatic hyperplasia, dihydrotestosterone and androgen receptor expression versus fnasteride in rats

2 de Septiembre de 2023

Invitamos a leer el artículo: “Tomato lipidic extract plus selenium decrease prostatic hyperplasia, dihydrotestosterone and androgen receptor expression versus finasteride in rats”, en la que colaboró la Doctora Guadalupe Bravo, Investigadora de Cinvestav Sede Sur

Autores: David Julian Arias Chávez, Patrick Mailloux Salinas, Jessica Ledesma Aparicio, Elihu Campos Pérez, Omar Noel Medina Campos, José Pedraza Chaverri y Guadalupe Bravo

Felicitamos al estudiantado y profesorado que contribuyeron en esta investigación por su arduo trabajo.

Abstract: Purpose Evaluate the therapeutic efect of a tomato lipidic extract (STE) in combination with selenium (Se) on rats with prostatic hyperplasia (PH) and to observe its possible mechanisms of action and synergism versus fnasteride.

Materials and methods 54 male Wistar rats of nine weeks old were divided in Control (C), PH, Finasteride (F), STE, Se, F+STE, F+Se, STE+Se and F+STE+Se with testosterone enanthate (except C). After 4 weeks of treatment administration, prostate weight, bladder weight, diuresis, prooxidant and antioxidant activity, dihydrotestosterone (DHT), androgen receptor (AR) expression and anatomopathological analysis were determined.

Results STE+Se decreased prostate weight 53.8% versus 28% in F group, also STE+Se decreased signifcatively glandular hyperplasia, prooxidant activity, DHT and AR expression and increased diuresis and antioxidant activity versus fnasteride which increased MDA in prostate.

Conclusions These results demonstrate a greater therapeutic and benefcial efect of tomato lipidic extract in combination with Se in young rats with PH with respect to fnasteride without increase prooxidant activity

Keywords: Prostatic hyperplasia, Dihydrotestosterone, Tomato, Selenium, Finasteride, Androgen receptor