Dr. Juan Pedro Luna Arias

Investigador 3C, SNI III

5557473800 Ext. 4016 Lab 5567

jpluna@cinvestav.mx

Líneas de investigación

• Regulación de la expresión genética
• Marcadores moleculares de diagnóstico y pronóstico de cáncer de mama
• Biología del Cáncer
• Biosíntesis y degradación de la pared celular
• Desarrollo de nanopartículas como sistemas acarreadores de drogas

Proyectos relevantes

• Regulación genética: función de TBP, TBPL1, TFIID TAF1 y choque térmico

• Marcadores moleculares en cáncer de mama

• Nanocompositos de hidroxiapatita-dendrímeros de PAMAM como transportadores de drogas.

• Producción de proteínas recombinantes de interés biológico.

• Función de exoglucanasas de Candida albicans.

Semblanza

Se doctoró en la Univ. Extremadura (Badajoz, España, 1994). Ha publicado 65 artículos, un libro, 12 capítulos, más de 91 ponencias Congresos. Tesis dirigidas: Doctorado (14), Maestría (18) y Lic. (19). Tutor de Doctorado (9), Maestría (2), Licenciatura (10). Pertenece a HUPO, ASBMB, AAAS, AMC, SMB. Coordinador Académico (2011-2019). SNI Nivel III

Publicaciones recientes y/o relevantes

• Lopez-Camarillo, C., Luna-Arias, J.P., Marchat, L.A. and Orozco, E. (2003). EhPgp5 mRNA stability is a regulatory event in the Entamoeba histolytica MDR phenotype. J. Biol. Chem. 278, 11273-11280. ISSN: 1067-8816 (Electronic). https://www.jbc.org/article/S0021-9258(19)32411-1/fulltext

• Karla Grisel Calderón-González, Ma Luz Valero Rustarazo, Maria Luisa Labra-Barrios, César Isaac Bazán-Méndez, Alejandra Tavera-Tapia, Maria Esther Herrera-Aguirre, Manuel M. Sánchez del Pino, José Luis Gallegos-Pérez, Humberto González-Márquez, Jose Manuel Hernández-Hernández, Gloria León-Ávila, Sergio Rodríguez-Cuevas, Fernando Guisa-Hohenstein, and Juan Pedro Luna-Arias. (2015). Determination of the protein expression profiles of breast cancer cell lines by Quantitative Proteomics using iTRAQ Labelling and Tandem Mass Spectrometry. J. Proteomics 124;50-78. http://www.ncbi.nlm.nih.gov/pubmed/25918110. ISSN: 1874-3919

• Benito Minjarez, Karla Grisel Calderon-Gonzalez, Ma. Luz Valero Rustarazo, Maria Esther Herrera-Aguirre, Maria Luisa Labra-Barrios, Diego E. Rincon-Limas, Manuel M. Sanchez del Pino, Raul Mena and Juan Pedro Luna-Arias. (2016). Identification of proteins that are differentially expressed in brains with Alzheimer’s disease using iTRAQ labeling and tandem mass spectrometry. J Proteomics. 139:103-121. ISSN: 1874-3919. https://www.ncbi.nlm.nih.gov/pubmed/27012543

• Miguel Ángel Ontiveros-Torres, María Luisa Labra-Barrios, Sofía Díaz-Cintra, Azucena Ruth Aguilar-Vázquez, Samadhi Moreno-Campuzano, Paola Flores-Rodríguez, Claudia Luna-Herrera, Raúl Mena, George Perry, Benjamín Florán-Garduño, José Luna-Muñoz, and Juan Pedro Luna-Arias. (2016). Fibrillar Amyloid-β accumulation triggers an inflammatory mechanism leading to hyperphosphorylation of the carboxyl-terminal end of Tau polypeptide in the hippocampal formation of the 3×Tg-AD transgenic mouse. J Alzheimer Disease. 52;243-269. ISSN: 1387-2877 (P); ISSN: 1875-8908 (E). https://www.ncbi.nlm.nih.gov/pubmed/27031470

• Fabiola Vázquez-Hernández, Salvador Mendoza-Acevedo, Claudia Oliva Mendoza-Barrera, Julio Mendoza-Álvarez, and Juan Pedro Luna-Arias (2017). Antibody-coupled hydroxyapatite nanoparticles as efficient tools for labeling intracellular proteins. Materials Science and Engineering C 71: 909–918. ISSN: 0928-4931. https://www.ncbi.nlm.nih.gov/pubmed/27987788.

• Ravi Kumar Narayanasamy, Carlos Alberto Castañon-Sanchez, Juan Pedro Luna-Arias, Guillermina Garcia-Rivera, Bartolo Avendaño-Borromeo, María Luisa Labra-Barrios, Jesús Valdés, María Esther Herrera-Aguirre, and Esther Orozco. (2018). The Entamoeba histolytica TBP and TRF1 transcription factors are two GAAC-box binding proteins, which display differential gene expression under different stress stimuli and during the interaction with mammalian cells. Parasit Vectors. 11(1):153. doi: 10.1186/s13071-018-2698-7. ISSN: 1756-3305. https://www.ncbi.nlm.nih.gov/pubmed/29514716

• Elizabeth Reyna-Beltrán, María Iranzo, Karla Grisel Calderón-González, Ricardo Mondragón-Flores, María Luisa Labra-Barrios, Salvador Mormeneo, and Juan Pedro Luna-Arias. (2018). The Candida albicans ENO1 gene encodes a transglutaminase involved in growth, cell division, morphogenesis and osmotic protection. J Biol Chem. 293(12):4304-4323. M117.810440. doi: 10.1074/jbc.M117.810440. ISSN 1083-351X. https://www.ncbi.nlm.nih.gov/pubmed/29386353.

• Bartolo Avendaño-Borromeo, Ravi Kumar Narayanasamy, Guillermina García-Rivera, María Luisa Labra-Barrios, Anel E. Lagunes-Guillén, Bibiana Munguía-Chávez, Carlos Alberto Castañón-Sánchez, Esther Orozco, Juan Pedro Luna-Arias (2019). Identification of the gene encoding the TATA-box binding protein associated factor 1 (TAF1) and its putative role in the heat shock response in the protozoan parasite Entamoeba histolytica. Parasitol Res. 118(2): 517-538. ISSN: 0932-0113 (Print) 1432-1955 (Online). https://www.ncbi.nlm.nih.gov/pubmed/30552577. PMID: 30552577. DOI: 10.1007/s00436-018-6170-6.

• Bioinformatics Tools for Proteomics Data Interpretation. Modern Proteomics Adv Exp Med Biol 919 Springer.

• Quantum dots for biomedical applications; 20 Use of nanostructure materials in drug delivery. Nanobiomaterials. Nanostructured Material for Biomedical Applications. Woodhead Publishing Elsevier

Dr. Walid Kuri Harcuch Dr. Fernando Navarro-García